A California native, Christina Applegate made her acting debut at five months old, when her mother landed her in a commercial for Playtex nursers.
Since then her career Applegate had a number of small parts before earning her breakout role in Married with Children in 1987. She has also appeared in films like The Big Hit, Don't Tell Mom the Babysitter's Dead, Mars Attacks! and The Sweetest Thing. She was married to actor Johnathon Schaech for six years before their divorce in August 2007.
In 2008, it was announced that Applegate has been diagnosed with an early form of breast cancer. The actress is now cancer-free.
Applegate announced her engagement to musician Martyn LeNoble in April 2010. They married three years later. Applegate gave birth to the couple's first child, daughter Sadie Grace, in January 2011.