Like siblings Rosanna, Patricia, Richmond and Alexis, David Arquette was bitten by the acting bug at an early age.
After starring in a number of minor roles, his big break came in 1992 as Luke Perry's best friend in Buffy the Vampire Slayer.
However, it wasn't until 1996's hit slasher film Scream that his success professionally, and privately, began to really take off.
On set he met Friends star Courteney Cox and the two married in 1999. Together they have a daughter named Coco.
Arquette has since starred in a number of box office busts like 2006's The Tripper and 2005's Slingshot.
After 11 years of marriage, Arquette and Cox announced they were separating in October 2010.