The cohost of E! News, the E! network's flagship entertainment news program, Rancic was born in 1974 in Naples, Italy. The recognizable face often cohosts red carpet events for award shows alongside Ryan Seacrest, including the Golden Globes and the Academy Awards.
Aside from hosting, she indulged her literary side when she wrote the book Think Like a Guy: How to Get a Guy by Thinking Like One in 2006.
In September 2007, the journalist married Bill Rancic in a ceremony on Capri. The couple's first reality show, Giuliana and Bill, premiered on the Style Network in August 2009. Throughout the show, the couple opened up about their struggles to conceive a child. In 2010, prior to the show's second season, Giuliana announced she suffered a miscarriage on The View.
In October 2011, Giuliana revealed that the couple's third IVF attempt would be put on hold as she received treatment for early stage breast cancer. The couple welcomed their first child, Edward Duke Rancic, via gestational surrogate in August 2012.