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Chelsea Handler does not regret calling Angelina Jolie a "homewrecker" or a "f***ing b**ch" during a talked-about standup routine in Newark, NJ over the weekend.

The comedienne addressed the quasi-controversy on her late-night talk show Chelsea Lately Monday night -- and suggested that her tirade against Jolie, 35, had absolutely nothing to do with Handler's close pal Jen Aniston.

"I've been making fun of Angelina Jolie since she made out with her brother!" Handler quipped. (Jolie famously locked lips with her brother James Haven at the Oscar ceremony in 2000, the year of Brad Pitt and Aniston's weddding; Jolie and Pitt hooked up about five years later.)

Maybe Handler should freshen up her routine, then? "If I've learned anything from this, it's to write some new jokes," she admitted.

During her Friday night show -- rumored beau 50 Cent watched in the wings -- Handler dug into Jolie's famous brood of kids: "She can rescue as many babies from as many countries as she wants to...'I don't f***ing believe you."