Credit: Lester Cohen/WireImage.com

Neither Courteney Cox nor David Arquette "is holding up great, but they are adjusting to life on their own again," a family source tells the new Us Weekly (now on newsstands) of the couple, who shocked fans Monday by announcing that they have separated after 11 years of marriage.

Arquette, 39, is relying on his siblings, including Medium star Patricia, for support.

Meanwhile, Cox’s BFF, Jennifer Aniston, in a role reversal, is playing the part of comforter.

“Courteney is leaning on Jen,” says a source.

Cox, 46, cared for Aniston, 41, after her divorce from Brad Pitt and a string of other dead-end relationships, including John Mayer and Bradley Cooper.

Perhaps that is why Cox just couldn't take care of Arquette anymore, he suggested in a very candid Howard Stern interview Tuesday.

"She tries to take on everybody's problems," he said. "She's the mother to everyone. That's why she doesn't want to be the mother to me anymore."

For their 11th wedding anniversary this past June, he said she bought him a motorcycle. "She said to me, 'I don't want to be your mother anymore,'" he recalled.