Director Peter Farrelly and director Bobby Farrelly arrive to the premiere of Warner Bros. Pictures' "Hall Pass" on February 23, 2011 in Los Angeles, California. Credit: Alberto E. Rodriguez/Getty

Bobby Farrelly, the director (alongside brother Peter) behind smash comedies There's Something About Mary, Me, Myself and Irene and other hits, is in mourning.

His 20-year-old son Jesse died on Wednesday evening in Orange County, Calif. of an apparent drug overdose, TMZ reports. He is survived by parents Bobby and Nancy and sisters Anna and Tiffany.

"It is with profound sorrow that we accept the passing of our beloved Jesse following his struggle with addiction. We fully trust that he is now in the hands of our Lord," the Farrelly family told Us Weekly in a statement.

"We are immeasurably grateful for the abundance of happiness and laughter he brought into our lives, and we will rejoice eternally for all the moments we got to breathe in his wondrous spirit," the statement continued. "The family thanks you for your well wishes and kindly asks that you respect our privacy during this difficult time."

According to TMZ's report, Jesse was found unresponsive at an apartment in Cosa Mesa, Calif. Wednesday evening; paramedics transported him to the hospital, where he was soon pronounced dead.

He had brief cameos in his father and uncle's films Hall Pass and There's Something About Mary. The Farrelly Brothers' next film is their remake of The Three Stooges, currently in post-production.