The Sleepless in Seattle actress, 52, and singer, 62, dated for more than three years. "The distance got to be too much," a source close to the pair tells Us. Mellencamp resides on a farm in Indiana while Ryan lives in New York.
The rocker has also been busy prepping for his new album Plain Spoken.
Ryan and Mellencamp first stepped out in 2010, just months after the "Troubled Man" singer split from his wife of eighteen years Elaine Irwin Mellencamp. Ryan was previously married to Dennis Quaid, they divorced in 2001.