Mo'Nique got to know Sandra Bullock very well this year, as both attended countless award shows together -- and picked up Academy Awards.
Now, as Best Actress Oscar winner Bullock, 45, battles allegations that her husband Jesse James, 40, had an affair with a tattoo model, the Precious star, 42, wants her to know she's there for her.
"To my sweet sister Sandra, my prayers are with you," the Best Supporting Actress winner said on Entertainment Tonight Monday. "My prayers are also with your husband, baby. That is between the two of you and I hope ya'll make it work.
"It's hard," Mo'Nique went on, "but that's their business. Let them go through their situation ... I don't wish her nothing but happiness, along with her husband. ... I don't want to see any marriages dissolve or break up."
Before the interview ended, she said: "Sandra, if you need me, sugar, call me, baby..."
Interestingly, Mo'Nique - who has known her husband Sidney Hicks for 25 years - has an open marriage.
"Could Sid have sex outside of his marriage with me? Yes. That's not a deal-breaker," she recently told Barbara Walters. "That's not something that would make us say, 'Pack your things and let's end the marriage.'"
She said it didn't matter if he had numerous flings, either.
"What if it's 20 times?" she said. "So what? We've been best friends for over 25 years, and we truly know who we are. Oftentimes, people get into marriages and they don't know who they're laying next to. I'm very comfortable and secure with my husband."