Originally titled Don't Mess With Texas, Hot Pursuit stars Witherspoon, 38, as a police officer who has been sent to retrieve a key witness, played by Vergara, 42.
Officer Cooper's police department is attempting to prosecute the leader of a drug cartel, and needs Daniella Riva, the wife of a drug lord, to testify against him. As the two attempt to travel back to the station, they are faced with murder plots, setups, and shenanigans along the way.
Witherspoon and Vergara star in the uproarious flick alongside Jim Gaffigan, Rob Kazinsky, and John Carroll Lynch, among others. Led by director Anne Fletcher (Step Up), Hot Pursuit is scheduled to hit theaters on May 8.
Catch Witherspoon and Vergara in the video above!