Take a look back at the siblings' lives with dad Tom Cruise, mom Nicole Kidman and ex-stepmom Katie Holmes
Cruise and Katie Holmes, whom he married in 2006 after welcoming their daughter Suri, supported Isabella at her soccer game in Los Angeles. "My kids don't call me Mommy,'" Kidman told GMTV in a 2007. "They don't even call me 'Mom.' They call me 'Nicole,' which I hate and tell them off for it."