Brandi Glanville had a sense of humor failure during her Tuesday, Jan. 6 appearance on Andy Cohen's Watch What Happens Live show, tossing a glass of wine over fellow guest Jeff Lewis for making a joke about STDs.

Cohen's Bravo chat show aired right after the latest episode of Glanville's The Real Housewives of Beverly Hills, which had already seen her chuck a glass of wine over new housewife Eileen Davidson.

And proving the wine splash to be her default anger reaction, Glanville gave Flipping Out star Lewis his own surprise when he made an unappreciated joke about her and an STD.

Cohen had asked Glanville, 42, if she could run her fingers through Lewis' hair to prove he didn't wear a toupee. The blonde Housewife had refused to do that to her fellow guest, but then Lewis made a quip, asking Cohen, "Could I get an STD from that?"

The joke didn't appear to cause Glanville great distress, but when the show returned after a commercial break she wanted to revisit to the topic.

"Before I do this I have something to say to Jeff about the whole 'can you get an STD from me putting my hands through his hair,'" she said. "As long as you wet it...." she continued, flicking the contents of her wine glass at his head to gasps of shock from the crew, "I think you'll be fine."

A shocked Cohen said the pair had just been talking in the commercial break and had seemed fine. Glanville replied that although Lewis had said he was joking, and apologized, she had written about getting an STD (from ex-husband Eddie Cibrian) in her book, so the joke was too close to the bone.

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Lewis, feeling bad, apologized again, at which point Glanville broke down into tears! “I’m taking five,” she said, sobbing.

Watch the outrageous episode in the clip above, and see how Glanville manages to sneak in some book promotion despite her crying fit!