Credit: Lester Cohen/

Jennifer Aniston is guest starring alongside BFF Courteney Cox on the season 2 premiere of Cougar Town, ABC announced Monday.

The show airs Sept. 22.

Aniston, 41, will play a "shrink named Bonnie" to Cox's character Jules, the show's executive producer Bill Lawrence tells Entertainment Weekly.

"Kind of a get-too-involved-in-her-life-type of therapist," Lawrence explains. "Those guys are so close in real life they kind of do that for each other anyway. Bonnie has the life Jules wishes she has."

Might Aniston's role become a recurring one?  "We're very intentionally implying that it's a therapist Courteney has been using for a while, and we're certainly not going to make it like they'll never see each other again," Lawrence says. "So I'm crossing my fingers that if she has a good time it'll happen again."

It is the third time the BFFs have shared the small screen.

They famously costarred on the hit NBC sitcom Friends. In 2007, Aniston guest starred on Cox's short-lived FX drama Dirt. On the episode, they famously locked lips.

Aniston could use some career buzz: Her latest comedy, The Switch, bombed at the box office this weekend, debuting at No. 8 with $8.1 million.