Most Valuable Bridesmaid!

Melissa McCarthy nabbed her first-ever Academy Award nomination on Tuesday, getting a Best Supporting Actress nod in comedy blockbuster Bridesmaids. She'll vie against Octavia Spencer (The Help), Janet McTeer (Albert Nobbs), Berenice Bejo (The Artist) and Jessica Chastain (The Help).

How did the Emmy-winning actress, 41, outshine an unforgettable cast that also included Kristen Wiig, Maya Rudolph and Rose Byrne?

Us Weekly asked fans on Facebook to weigh in on McCarthy's best moments and quotes from Bridesmaids, in which she played intense, quirky bridesmaid Megan. Us recaps the highlights below.

-"I'm glad he's single, 'cause I'm gonna climb that like a tree!" -- Eying an elderly man at an engagement party

-"I'm sorry. I won't apologize. I'm not confident which end that came out of." -- During the infamous bridal shop scene, in which Megan and the other women quickly succumb to major gastrointestinal distress

-"Can you feel that steam heat?" --Hitting on Air Marshall Jon (Ben Falcone, her real-life husband), blocking his way with her leg, aboard a flight bound for Las Vegas

-Puppy theft! At Helen's (Byrne's) over-the-top, Paris-themed bridal shower for Lillian (Rudolph), Megan gets greedy with the "party favors" -- taking home nine puppies versus the allotted one-per-guest

-Big Bear Sandwich! In the closing credits, Megan and beau Jon film a kinky sex tape with a hefty submarine sandwich as their prop

Tell Us: What's your favorite McCarthy moment from Bridesmaids?