In a video for the May 26 event, the actors finish each other's sentences — literally — to promote the good cause. Other stars featured include Chloë Grace Moretz, Kristen Bell, Ellen DeGeneres, Liam Neeson, Anna Kendrick, Lena Dunham, Vince Vaughn, Tracy Morgan and Will Ferrell.
Red Nose Day was created in the U.K. and launched for the first time in the U.S. last year. Walgreens joined in on the fun to help raise money, and has sold more than 10 million red noses so far.
Looking like a clown isn't the only way to help out. Donations can be made during NBC's Red Nose Day telecast. The two-hour special will be packed with amusing gags, skits and speeches on how to lend a hand.
The second annual Red Nose Day special airs on NBC on Thursday, May 26, at 9 p.m. ET.
Watch the Red Nose Day video above!
Can't get enough of Us? Sign up now for the Us Weekly newsletter packed with the latest celeb news, hot pics and more!