Credit: Steve Granitz/

Sandra Bullock is back on the clock!

Warner Bros. confirms to the Oscar-winning actress, 46, will star opposite George Clooney, 49, in the space drama Gravity, as a a female astronaut trying to get back to Earth after an asteroid ravages the space station she’s on.

Bullock, who stepped out of the spotlight following ex-husband Jesse James' cheating scandal earlier this year, is taking on the role once set to go to Angelina Jolie. (The Tourist star left to pursue other projects.) It's her first confirmed film project since her hit, The Blind Side, hit theaters last year.

Filming is set to start next spring after Clooney finishes up his directing work on the political drama Ides of March.

Bullock was recently spotted hitting up a pal's holiday bash in Tujunga, California Saturday with her festively-dressed 11-month-old son Louis.

"He's a little Cajun cookie," she has said of her tot.