Patrick Dempsey attends the Made of Honour celebrity screening on April 21, 2008 in London, England.
Jon Furniss/WireImage.com

McDreamy may not know how to make a marriage last on Grey’s Anatomy — but Patrick Dempsey sure does!

“Love, humor and communication — those are the bedrocks of a good relationship,” the Versace-clad Dempsey, 42, told Usmagazine.com Monday at the NYC premiere of his wedding-themed romantic comedy Made of Honor.

He plays a compulsive womanizer in the comedy, but he insisted the character's "nothing like me at all — I'm married and have kids!"

Of wife Jillian, the father-of-three said, "She's immensely supportive. Without her, I wouldn’t be here.”

So does Dempsey — who recently revealed he has pec envy — have any funny memories from their 1999 nuptials?

“The photographers were just drunk and never got a good picture!” he joked.

Click here to see the love lives of the Grey's Anatomy cast.

Dempsey’s new comedy, Made of Honor, hits theaters May 2.

Cheryl Burke "Concerned" Injured Cristian de la Fuente Will Be Voted Off