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Justin Timberlake, Jessica Biel Break Up

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Cry him a river!

After four years together, on-again/off-again couple Justin Timberlake and Jessica Biel have broken up.

Related: PHOTOS: Justin and Jessica in happier times

In a joint statement, reps for the couple confirm to, "Addressing the media speculation regarding Jessica Biel and Justin Timberlake's relationship, we are confirming that they mutually have decided to part ways. The two remain friends and continue to hold the highest level of love and respect for each other."

Related: PHOTOS: Sad Hollywood splits

"It was mutual," says an insider. "Jessica is doing well."

Singer-actor Timberlake, 30, began dating actress Biel, 29, in January 2007 — right on the heels of Timberlake's late 2006 split from Cameron Diaz, whom he dated for about three years.  (Biel dated actor Chris Evans, her costar in the flick Cellular, from 2001 to 2006).

Related: PHOTOS: Justin's style evolution

From the moment their romance began, The Social Network star and A-Team actress were often the subject of split and cheating rumors.

Related: PHOTOS: The many women Justin Timberlake has dated

Last year, Biel told Vogue of her relationship, "It's the most precious thing that I have in my life, and I care so much about it that I don't care about what anyone else says or thinks."

The former star of Seventh Heaven also admitted to the mag it wasn't always easy being the subject of so much media scrutiny regarding her love life. "It's definitely been weird and sort of bizarre to deal with," she said. "But you have to have a sense of humor about the whole thing."

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