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It's really over for Demi Moore and Ashton Kutcher.

"It is with great sadness and a heavy heart that I have decided to end my six-year marriage to Ashton," a rep for Moore, 49, tells Us Weekly in a statement Thursday.

"As a woman, a mother and a wife there are certain values and vows that I hold sacred, and it is in this spirit that I have chosen to move forward with my life," Moore's statement continues.

Kutcher, 33, infamously had a one-night stand with San Diego party girl Sara Leal, 22, in the wee hours of Sept. 24 of this year -- Kutcher and Moore's sixth wedding anniversary.

Margin Call actress Moore adds in her statement: "This is a trying time for me and my family, and so I would ask for the same compassion and privacy that you would give to anyone going through a similar situation."

It was the first marriage for Two and a Half Men star Kutcher, and the third for Moore, who divorced singer Freddy Moore in the mid-1980s, and fellow actor Bruce Willis in 2000. Married for 13 years, she and Willis, 56, share three daughters: Rumer, 23, Scout, 20, and Tallulah, 17.

Just last weekend, Willis hosted the embattled couple at his vacation home in Turks and Caicos, where Moore and Kutcher gave one last shot at repairing their union.  "They had to get away," a source told Us. "Things have been very strained."

But Moore's Thursday statement confirms she finally made up her mind. Just a few weeks ago, pals told Us that the star, though reeling from the split (and showing off an increasingly frail frame) wasn't ready to let go. "She's totally humiliated and angry, but she doesn't want him to leave her," a pal told Us in late October.