Chelsea Handler is setting up a clique of the most powerful women in Hollywood Credit: Eric Charbonneau/Invision for Warner Bros./AP Images

You can't sit with us! Irreverent talk show host Chelsea Handler is surrounding herself with Hollywood's most elite females. In fact, a source reveals in the new issue of Us Weekly that Handler is "setting up a clique of power women."

The E! host, who is set to make the move to Netflix with her own original programming after seven years of Chelsea Lately, recently feted Sandra Bullock for her 50th birthday and the insider tells Us, "Sandra fits right in [with her clique.]"

Handler, 39, along with seven friends including Whitney Cummings, 31, joined the Oscar winner in Jackson Hole, Wyoming, where they took in a July 24 show from the Southern Soul All Stars at the famed Million Dollar Cowboy Bar to celebrate the leading lady's birthday.

Bullock, who turned the big 5-0 on July 26, "wanted to let loose and talk dirty," an insider says of the getaway bash. 

Handler is also tight with A-listers Reese Witherspoon and Jennifer Aniston. And it won't be hard for Sandy to mingle with Handler's BFF Aniston—another insider revealed to Us the two have become good friends recently after meeting at a dinner hosted by Gwyneth Paltrow. "Jen and Sandra are new BFFs," the insider says. "They're very excited about the new friendship."