Credit: Gregg DeGuire/FilmMagic

She's been linked to 50 Cent and Animal Planet's Dave Salmoni, but Chelsea Handler's one true love will always be alcohol.

"Vodka is a part of my life. Absolutely. Tequila or vodka, depending on the day you get me," Handler, 36, told Us Weekly at Saturday's NBC Universal TCA Tour in Pasadena, Calif. "But to function as I do, I cant be a mess."

Though she once spent the night in jail for a DUI, Handler said she's become more responsible when she decides to imbibe.

"I feel a big responsibility to not only everyone who watches the show, but to everyone who is on the show and all the employees I have," the Chelsea Lately host and executive producer explained. "We're creating jobs in a landscape where people aren't getting a lot of work. Our show is a great place to be, and when you walk in the door, you know it."

The Are You There, Vodka? It's Me, Chelsea author added that "once everything's done, smoke what you need to smoke -- that's fine. Do it in the office. I really don't care."

Despite her hectic schedule -- she also stars on E!'s After Lately and NBC's Are You There, Chelsea? -- the New Jersey native assured Us she's getting plenty of rest.

"I got a lot of sleep, don't you worry. If I get home on a Monday at 7 o'clock and I know I don't have to be anywhere until 10 the next morning, I go to bed at 8," Handler said. "I take a sleeping pill and sleep for 12 hours."