James Keach and Jane Seymour Credit: J. Countess/Getty Images

Jane Seymour's marriage -- her fourth -- is over. After 20 years together, the British actress, 62, and actor-director husband James Keach have split, they announced Friday, April 12. "Jane Seymour and James Keach confirm that they are separated and have been for several months," the couple said in a statement to  Us Weekly.  "At this time they are negotiating the terms of their divorce."

Seymour wed American-born, twice-divorced Keach, 65 (who directed the star in her smash TV show Dr. Quinn, Medicine Woman) in 1993, and they share twin sons John and Kristopher, 17. Continue the pair in their statement: "They will continue their relationship as devoted parents to their children, as business associates and partners, and in their joint dedication to preserving and furthering the charitable endeavors that they've worked on throughout their marriage."

With four children overall, Seymour was previously wed, briefly, director Michael Attenborough and Victor Planer; she and David Flynn were married for ten years and share kids Katherine, 31, and Sean, 28.

Now a grandmother of three, the Emmy- and Golden Globe winning actress recently guest-starred on an episode of Franklin & Bash.