This family feud runs deep. Dina Manzo opened up to Andy Cohen and her fellow Housewives during the season 6 reunion of Bravo's Real Housewives of New Jersey about her continued estrangement from her brother Chris Laurita, his wife Jacqueline, and big sister Caroline Manzo.

Cohen first asked Dina, 43, about her relationship with her autistic nephew Nicholas, the 5-year-old son of Jacqueline and Chris. "I don't know Nicholas at all," she responded, adding that she has a photo of him on her dresser and she prays for him. "The work that I do, I see children… and he's progressing," she continued.

The hard-hitting Bravo host, 46, also posed a tough question about whether Dina would meet Nicholas if she were invited by the Lauritas. "Probably not," she responded. "I have to say what hurts me more is my daughter. That's her godfather and she grew up with [Chris]. I'm more bothered for the kids who understand."

Dina went on to rehash her epic and mysterious feud with Jacqueline, Caroline, and her brother. The mom of one revealed she had invited the entire gang to her daughter Lexi's high school graduation party this past June, but wasn't asked to attend her niece Lauren Manzo's engagement party.

"I invited everybody to Lexi's graduation party. Jacqueline, Chris, Caroline, the kids," Dina recalled.

"And did they come?" Cohen asked.

"No," Dina responded, point-blank.

Watch above to find out more details about Dina's estrangement from her siblings, plus what bothers her most about this family feud.

Tune in to The Real Housewives of New Jersey reunion special on Sunday, Nov. 2, on Bravo at 9 p.m. ET.