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Jen Aniston Jokes About Love Life

Jennifer Aniston can laugh about her love life.

At Friday night's Women in Film Awards in Culver City, Calif., host Chelsea Handler presented the actress, 40, with the Crystal Award for Excellence in Film. "You have increased the visibility of women in film, and we thank you for that," Handler said. "You've recently decreased the visibility of John Mayer, so we thank you for that."

Look back at Jen and John's most romantic moments.

Aniston's reaction? "Jen threw her head in her hands and was laughing so hard," a witness tells "Her two girlfriends on either side started laughing hysterically."

See all of Jen's men over the years.

Aniston kept the joke going when accepting her award. "I have a strange parallel with movies I was doing and my life off screen. First, it was The Good Girl…which evolved into Rumor Has It, followed by Derailed," she said, perhaps making a quip about her marriage with Brad Pitt, who left her for Angelina Jolie.

Relive Jen and Brad's happier days.

"Then there was The Breakup," she continued. "Followed by the lighter side, Friends With Money. If anyone has a movie called Everlasting Love With an Adult Stable Man, that would be great!" Aniston joked. "I'm at table six, and my agents are at table 12."

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