Heather Locklear and Kristin Davis: Then
The two starred in the classic ’90s night soap Melrose Place (1992-1999).
’90s TV Stars: Then & Now
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Heather Locklear and Kristin Davis: Now
After a DUI arrest, Locklear, 47, starred in the Lifetime movie Flirting with Forty, while Davis, 43, found success with the Sex and The City franchise and movie.
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Jodie Sweetin: Then
The child actress played Stephanie Tanner on the sitcom Full House (1987-1995).
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Jodie Sweetin: Now
After recovering from an addiction to meth, the married 26-year-old gave birth to her first child, Zoie Laurel May, in April.
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Tia and Tamera Mowry: Then
The real-life twins played twins separated at birth in Sister, Sister (1994-1999).
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Tia and Tamera Mowry: Now
Now 30, Tia acts on The Game and married her longtime beau, Cory Hardrict, on April 20. Tamera co-starred in Hollywood Horror with Haylie Duff.
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Calista Flockhart: Then
The actress got her big break in the Fox drama-comedy Ally McBeal (1997-2002).
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Calista Flockhart: Now
The star of Brothers & Sisters, 44, adopted a son, Liam, in 2001 before meeting longtime beau Harrison Ford.
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Brandy Norwood and Usher Raymond: Then
Moesha (1996-2001) was a star vehicle for the young singer -- and R&B star Usher appeared on four episodes.
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Brandy Norwood and Usher Raymond: Now
Brandy, 29, chronicled her first pregnancy on the MTV reality series Special Delivery in 2002. Around the same time as the release of her fifth album, Human, she revealed her marriage to Robert Smith was fake. Usher, 30, went on to win five Grammy Awards and is now married with two sons.
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Elizabeth Berkley and Mario Lopez: Then
The teen stars played Jessie Spano and A.C. Slater on Saved by the Bell (1989-1993).
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Elizabeth Berkley and Mario Lopez: Now
Showgirls star Berkley, 34, now hosts Bravo's Step It Up and Dance while Lopez, 35, has competed on Dancing With the Stars, starred on Broadway's A Chorus Line and is now a host on Extra.
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Mark-Paul Gosselaar and Tiffani Thiessen: Then
The teens played romantic interests on Saved by the Bell (1989-1993).
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Mark-Paul Gosselaar and Tiffani Thiessen: Now
Gosselaar, 34, is now the father of two and stars in the TNT series Raising the Bar. Thiessen, 34, costarred in the short-lived drama What About Brian in 2007.
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George Clooney and Julianna Margulies: Then
The romance between their characters Doug Ross and Carol Hathaway was a defining plotline in the early seasons of ER (1994-present).
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George Clooney and Julianna Margulies: Now
The Oscar-winning actor, 47, who achieved critical and commercial success as a producer, writer and director, has expressed his reluctance to make a special return on ER during the show's final season. Margulies, 42, is married and gave birth to her first child last January.
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Claire Danes: Then
She starred opposite Wilson Cruz and A.J. Langer in the critically acclaimed 1994 drama My So-Called Life.
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Claire Danes: Now
The 29-year-old actress had been dating Evening costar Hugh Dancy last year. She starred in Stardust and 2008's Me and Orson Welles.
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Jennifer Love Hewitt: Then
The actress parlayed her role on Party of Five (1994-2000) into a short-lived spinoff called Time of Your Life (1999).
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Jennifer Love Hewitt: Now
The 29-year-old has been starring in Ghost Whisperer since 2005 and was engaged to Scottish actor Ross McCall since November 2007.
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Jasmine Guy: Then
As Whitley, the actress was usually the center of attention on the hit show A Different World (1987-1993).
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Jasmine Guy: Now
The 46-year-old -- who describes herself as an actress/singer/dancer/writer/producer -- filed for divorce from her husband of 10 years in April. They have a 9-year-old daughter, Imani.
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Melissa Joan Hart: Then
The teen starred in the Nickelodeon classic Clarissa Explains It All (1991-1994).
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Melissa Joan Hart: Now
The 32-year-old has stayed busy with TV movies, a marriage and two young sons, one of whom was born last March.
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Mayim Bialik: Then
The teen was the title character on Blossom (1991-1995), which co-starred Joey Lawrence.
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Mayim Bialik: Now
The actress received a Ph.D. in neuroscience from UCLA and is married with a two-year-old son. The 33-year-old has made appearances on Curb Your Enthusiasm and Fat Actress.
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Jennie Garth: Then
The actress played Kelly on the teen soap Beverly Hills, 90210.
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Jennie Garth: Now
The 36-year-old dropped out of an upcoming comedy pilot for CBS, and she went on to reprise her famous '90s role in the CW's 90210 spinoff.
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Neil Patrick Harris: Then
The star played a teen genius and licensed physician in the show Doogie Howser, M.D. (1989-1993).
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Neil Patrick Harris: Now
After breaking back into the spotlight with a cameo in Harold & Kumar Go to White Castle, the 35-year-old is now an Emmy-nominated actor in the CBS hit, How I Met Your Mother.
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Candace Cameron: Then
The child actress played D.J. Tanner Tanner on the sitcom Full House from the ages of 11 to 19 (1987-1995).
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Candace Cameron: Now
The married 32-year-old has three kids -- Natasha, 10, Lev, 8, and Maksim, 6 -- and recently appeared in the Hallmark Channel's Moonlight & Mistletoe.
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Danielle Fishel: Then
The bubbly brunette played Cory Matthews' longtime girlfriend, Topanga Lawrence, on Boy Meets World (1993-2000).
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Danielle Fishel: Now
Known for having dated former 'NSYNC bandmate Lance Bass -- who revealed he was gay in 2006 -- and being a spokesperson for NutriSystem, Fishel, 27, is now the host of the Style Network's pop culture show, The Dish.
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Kristen Johnson: Then
The bombshell played an alien, along with John Lithgow and Joseph Gordon-Levitt, named Sally Solomon in 3rd Rock from the Sun (1996-2001).
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Kristen Johnson: Now
After a year where she admitted to being "way too thin" after dropping 60 pounds following a burst ulcer, the 6-foot-tall star, 41, landed a supporting role in this year's wedding comedy, Bride Wars.
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