Chelsea Handler's not done taking sides in the great Aniston-Jolie Debate.
The outspoken comedienne once again trashed Angelina Jolie -- and oohed and aahed over pal Jen Aniston -- in a new interview with Katie Couric in Glamour.
Couric asked Handler, 35, about her recent onstage rant about Jolie, 35, at a Newark, NJ comedy show.
"Yeah, I'm not a fan," Handler said of The Tourist star. "She just doesn't come off to me as a sincere woman. She seems like a woman that you'd really want to avoid."
But 41-year-old Aniston (ex-wife to Jolie's love Brad Pitt) gets an A-plus from the Chelsea Lately hostess. "Jennifer Aniston makes me laugh," Handler says of the star, with whom she vacationed in Mexico. "She's irreverent and hilarious, and she sends me really, really funny e-mails."
Handler also pipes up about her friend 50 Cent."He came to my show in New Orleans with 15 people, and they take a photo of us and assume that we're a couple," she explains. (Still, the duo have been photographed together numerous times, and he cheered on her Newark show last Friday.) "But he's really cute, and I have to be honest, there's a good chance that I will end up hooking up with a rapper at some point."