Credit: Jason LaVeris/FilmMagic

After 17 years together, George Lopez and wife Ann are calling it quits.

In a statement to, a rep says: "George and Ann Lopez have made the decision to end their 17 year marriage. The decision is amicable and by mutual agreement. They remain dedicated parents, and committed partners in business and their philanthropic organization, The Lopez Foundation."

The comedian and late-night talk show host, 49, and Ann have a 15-year-old daughter, Mayan.