In the FYI talk show's preview clip, the host, 31, points out that Kourtney Kardashian's oldest child, 6-year-old Mason, was initially "confused" that his grandfather identifies as a woman.
"Mason was uncomfortable but [would] kind of, like, be distant to Caitlyn, but Caitlyn ... understood and handled it perfectly," Khloé says.
The Strong Looks Better Naked author adds that Kim Kardashian's 2-year-old daughter, North, and Kourtney's 3-year-old daughter, Penelope, are not as affected by the change.
"But the little ones, like North and P, they don't know the difference, which is the innocence of children," Khloé says. "They know her as just Caitlyn."
Watch the discussion in the video above.
Kocktails With Khloé airs on FYI Wednesdays at 10 p.m. ET.
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