Credit: Michael Buckner ; Jeff Kravitz ; Jemal Countess

Two and a Half Men may be off the air indefinitely as star Charlie Sheen continues to behave erratically -- but Sheen's unscripted antics have inspired comedy gold among his Hollywood peers via Twitter.

After Sheen said he "cured" his drug and alcohol addiction with his mind, comedienne Sarah Silverman sniped on the micro-blogging site: "If I hung out w 20 year old porn stars all the time time I'd think I was a genius too."

Actress Zooey Deschanel cracked: "MYSTERY SOLVED: now we know who the "half a man" is in "two and a half men."...HINT: it's not the kid!!!!"

Adding the latest Middle East crisis into the discussion, Rescue Me star Denis Leary opined, "Is it just me or is Charlie Sheen starting to sound a lot like Moammar Kaddafi?"

"How crazy is that Charlie Sheen rant?" E! News' Giuliana Rancic said, "Have u noticed he loves saying 'winning?'"

(During one typically bizarre radio interview, Sheen boasted, "I can't stop winning!")

"Unlike SOME people, I can stop winning whenever I want! #sorrycharlie," comic Andy Richter joked.

Meanwhile, John Stamos put a certain TV-casting rumor to rest. "Contrary to the rumors, i am not replacing Charlie Sheen on Two and Half Men. however, Martin Sheen has asked me to be his son."

Currently vacationing in the tropics -- with his ex-wife Brooke Mueller and two porn stars -- Sheen, 45, has at least one defender in CNN's Piers Morgan.

"Is it just me that thinks Charlie Sheen be allowed to behave how the hell he likes in his own time?" Morgan asked.