As the Queen of Talk signs off Wednesday, Us looks back at the best of Winfrey
All in the Family
Revealing the bombshell secret that she had a half-sister named Patricia, Winfrey welcomed her sibling on the show in 2011. "I thought I'd seen it all," Winfrey teased about the discovery. "But this, my friends, is the miracle of all miracles."
Credit: Harpo, INC/George Burns