Fallon's game consists of 16 glass panels, half painted with the late-night host's face and the other half belonging to the profile of his opponent. "Don't confuse the faces, we look very much alike," Fallon, 40, joked Thursday, explaining the rules of the popular show staple. "First person to smash all of their opponent's faces, wins!"
McConaughey, 45, appearing on the show in a gray three-piece suit, eagerly grabbed a football as Fallon shamefully told the audience: "Matthew's beat me twice on the show."
McConaughey went first, and with two consecutive throws (complete with perfect spirals!), he hit Fallon's glass panels square in the face. At one point, he even led Fallon 3 to 1.
The actor, a longtime football fan, has often expressed his love for the game, and even gave a motivational speech to the University of Texas' Longhorns football team (his alma mater) this past September.
His wild face-off against Fallon on Thursday included some smack talk and somehow, miraculously, a trailing Fallon caught up to his guest. Find out who wins above!
Sign up now for the Us Weekly newsletter to get breaking celebrity news, hot pics and more delivered straight to your inbox!