Kate Walsh, Seth MacFarlane Mock Charlie Sheen at Brutal Roast

Totally tasteless or epically awesome?

Charlie Sheen was the good-natured butt of one shocking joke after another at Comedy Central's roast, which aired Monday night.

The kinder, gentler actor, 46, was the dishonored guest of honor at the raunchy fest, hosted by Seth MacFarlane and featuring such roasters as Jon Lovitz, Kate Walsh, Jeffrey Ross, Mike Tyson, Anthony Jeselnik, Steve-O, Amy Schumer, William Shatner and Patrice O'Neal.

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What were some of the lowest blows and funniest insults about the star, who's famously battled drug and alcohol addiction, sparred with exes over his kids and partied heavily with strippers, porn stars and escorts?

Quipped Kate Walsh: "I have to say, Charlie, you are an incredible medical specimen. I guess that's one of the benefits of waking up every morning at the crack of crack...It's amazing -- after abusing your lungs, liver and kidneys, the only thing you've had removed is your kids."

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Said William Shatner, 80: "How come we look like we went to high school together?"

MacFarlane: "Charlie, you claim to have ‘tiger blood,’ but after all the porn stars you've [had sex with], it's probably Tiger Woods' blood."

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Steve-O: "Charlie still hasn't hit rock bottom. He's looking forward to it though, because he thinks there's a rock there."

Jeffrey Ross: "If you're winning, this must not be a child custody hearing. The only time your kids get to see you is in reruns -- don't you want to live to see their first 12 steps?"

Anthony Jeselnik: "The only reason you got on TV in the first place is because God hates Michael J. Fox."