Jennifer Aniston and Jason Sudeikis at the European Premiere of Horrible Bosses in London. July 20, 2011. Credit: AP Photo/Joel Ryan

If all goes well, Jennifer Aniston will reunite with her two-time costar Jason Sudeikis in the upcoming comedy We're the Millers.

Sudeikis, 36, has signed on to play a drug dealer who creates a faux family to smuggle 1,400 pounds of marijuana from Mexico into the U.S. According to The Hollywood Reporter and Deadline, Aniston, 43, is in talks to play his "wife," who also happens to be a hooker.

The raunchy comedy was written by Wedding Crashers' Bob Fisher and Steve Faber. Dodgeball's Rawson Marshall Thurber is attached to direct.

Aniston and Sudeikis first shared the screen in 2010's The Bounty Hunter (alongside Gerard Butler). They teamed up again in 2011 for the ensemble comedy Horrible Bosses, also starring Jason Bateman, Charlie Day, Colin Farrell, Kevin Spacey and Jamie Foxx.

Sudeikis, who hit it big on Saturday Night Live, was recently cast opposite his real-life love Olivia Wilde, 27, in the romantic comedy Relanxious.