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She goes after everyone from Oprah Winfrey to Sharon Stone, but comedian Kathy Griffin says one celeb is off limits: Sandra Bullock.

Given all the drama in Bullock's personal life (she filed for divorce from husband Jesse James in April after he cheated on her), "I really wouldn't make fun of her," Griffin, 49, told Tuesday at the Samsung Hope for Children gala in NYC.

In her first televised appearance since her split, a smiling Bullock, 45, told the audience at the June 6 MTV Movie Awards: "Can we please go back to normal? Therapy is really expensive. Go back to making fun of me."

Griffin said she thought the move was smart.

"I love when she said that comedians could make fun of her again," the Bravo star told Us. "I'm going to send her a muffin basket! She seems to have a sense of humor, but if I wanted to, she said I could! I thought she was talking to me through the TV."

But watch out, Heidi Klum and Seal -- Griffin may be going after you next!

"Happy people and positivity in general just make me angry," she quipped. "It makes me want to vomit! I believe in negativity and darkness."