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Make no mistake: Chelsea Handler is definitely, absolutely on Team Aniston!

During a stand-up comedy show in Newark, NJ over the weekend, Handler -- new BFF to Jennifer Aniston, 41 -- went on a foul-mouthed rant against Angelina Jolie.

"She's a homewrecker, she is," Handler, 35, said of Jolie, the current of love of Aniston's ex Brad Pitt.

"She can rescue as many babies from as many countries as she wants to," the comedienne continued of the star, who has adopted three kids from around the world. "I don't f***ing believe you. She gives interviews, 'I don't have a lot of female friends.' Because you're a f***ing c*** ," Handler bellowed.

"You're a f***ing b***h!"

Handler and Aniston spent Thanksgiving weekend together with other female pals in Los Cabos, Mexico.

The Chelsea Lately's hostesses' one complaint about the sunny getaway: "I was trying not to get photographed next to her in a bathing suit, for obvious reasons," Handler quipped last week.