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No joke: Chelsea Handler and 50 Cent are dating, a source confirms to

The unexpected pair were photographed looking romantic at a New Orleans bar on Sunday.

"It's been going on awhile," the source says of the comedienne and the rapper, both 35. "It's more of a hookup thing -- whenever they are in the same town."

50 Cent's rep had no comment. A rep for the Chelsea Lately host tells Us, "She saves all her comments for her own show."

In September, Handler parted ways with Animal Planet star Dave Salmoni after about two months of dating. 50 Cent (real name: Curtis Jackson) briefly dated actress Vivica Fox in 2003, and has a son, Marquise, 12, with ex-girlfriend Shaniqua Tompkins.