Bye-bye, Mickey Mouse, hello, "ghost face" killer!

It was back to work for Courteney Cox and David Arquette in Hollywood on Monday. Less than a week after the estranged spouses treated daughter Coco, 6, to a Disney World jaunt, the pair appeared on their first red carpet together since their September 2010 split.

Cox, 46, and Arquette, 39, joined Neve Campbell, Anna Paquin, Hayden Panettiere, Shenae Grimes, Emma Roberts, Kristin Bell and other stars for Scream 4, the latest installment on the classic horror franchise; Cox and Arquette famously fell in love on the set of the first Scream way back in the mid-90s, tying the knot in 1999.

Speaking to on the red carpet, Arquette continue to explain that he and Cox (who had a romantic getaway with Cougar Town costar Josh Hopkins) are amicable -- but not reconciling.

 "We love each other and we’re a family and we will be together forever, whether we are married or not," he told Us.

See how everyone looked at Monday's star-studded premiere --check out the video now!