Does Brad Pitt have a shot at stealing the Best Actor in a Motion Picture trophy from George Clooney at the 84th Annual Academy Awards Sunday?

Us Weekly senior editor Bradley Jacobs consulted Johnny Avello, executive director of race and sports operations at Wynn Las Vegas, to find out who's the odds-on favorite.

"In the past Brad Pitt's looks have worked against him," Jacobs explains. "This year he found a great role for himself playing real life baseball manager Billy Beane. He showed heart, he was articulate, he was very smart, and for a while there, people thought he might even win the Oscar."

Unfortunately for Angelina Jolie's partner, The Descendants' Clooney, 50, has 5 to 6 odds of nabbing the win. "He played a grieving dad, he had a big crying scene, he gained a little bit of weight -- everybody loves this role for him."

Jean Dujardin (The Artist), Demian Bichir (A Better Life) and Gary Oldman (Tinker Tailor Soldier Spy) are also nominated in the Best Actor in a Motion Picture category.

Many industry experts predicted Meryl Streep would win the Best Actress in a Motion Picture award for her role as Margaret Thatcher in The Iron Lady, but "she hasn't won in 29 years," Jacobs points out.

"When critics finally saw the movie, they loved Meryl as Margaret Thatcher, but the film? Not so much. That may hurt her on Oscar night."

The front-runner is The Help's Viola Davis, 46, who "gained a lot of momentum for her portrayal of a southern maid in 1962." She has a 14 to 1 lead over Streep (6 to 5).

Michelle Williams (My Week With Marilyn), Glenn Close (Albert Nobbs) and Rooney Mara (The Girl With the Dragon Tattoo) are also nominated in the Best Actress in a Motion Picture category.

For more Academy Awards predictions, watch the video (above), follow Bradley Jacobs' Twitter account, and tell Us: who are you rooting for?