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Reese Witherspoon, Monsters vs. Aliens
The star played Susan Murphy, a woman hit by a meteor on the day of her wedding in the 3-D flick that came out in March. The incident causes her to grow to the height of tall buildings, and she's named "Ginormica" by the government. She's taken to a secret compound with a ragtag group of other monsters.
Credit: Jeff Vespa/WireImage.com; Dreamworks