Credit: Jason Merritt/Getty

Attention, ladies: George Clooney is back on the market.

After two years together, he and Italian actress/model Elisabetta Canalis have called it quits. "We are not together anymore," the duo tells Us Weekly in a joint statement. "It's very difficult and very personal and we hope everyone can respect our privacy."

All seemed well for the jet-setting pair -- who spent tons of time together, often with their families, at Clooney's Lake Como estate in Italy -- recently.

"I am very happy at the moment - thanks to my man and my fairytale is continuing," Canalis, 32, told Italian magazine Chi in its June issue. "We are a couple that never gets bored."

But the notoriously private Clooney, 49, revealed in January that he wouldn't wed again -- not Canalis or anyone, for that matter.

"I was married," he quipped on Piers Morgan Tonight. "I gave it a shot." (Clooney and actress Talia Balsam were wed from 1989 to 1993.)

Yet Canalis seemed less averse to walking down the aisle. "I am a firm believer in marriage," she told Chi.  "In the future I will be married, but for the time being I am happy as I am," she says. "I don't need anything to confirm how happy I am."

"[George] reassures me all the time," Canalis said in a late 2010 chat with Italian Vanity Fair. "I feel more embraced than ever before. The idea of being so loved is overwhelming...George has given color back to my life."