The comedian, 41, was joined by outgoing California senator Barbara Boxer for the emotional sit-down.
"The election is over, and obviously the result is not what I was hoping for," Handler told the audience. "Like a lot of people in this country, I'm sad, I'm disappointed, and I'm confused. But if Hillary can make it through a concession speech, then I can make it through a stupid television show. So I'm going to. I'm taking her lead. She said we can do it, so I'm going to do it for every woman out there."
Boxer, 75, agreed, and encouraged disappointed voters to power through their sadness. "My heart is on the floor, and I think the first thing to do when something like this happens is admit that," she said. "We need to move forward, and that's it. That's what life is about. That's what we are taught, that it's not where you are when you are high and doing great, it's when you fall down. … I have learned how painful politics can be, but that doesn't mean you run away."
Boxer, who has held a seat in the Senate since 1992, has a family connection to the former secretary of state, 69. Her daughter, Nicole, married Tony Rodham, Clinton's youngest brother, at the White House in 1994. Boxer is retiring after 2016. On Tuesday, State Attorney General Kamala Harris was elected to replace her, becoming the first black politician in history to represent California in the Senate.
"I know for a woman and as a woman it feels so sexist, and I guess the message I want to spread out to other women is exactly what you're saying. It's to not give up — sorry, I hate f—king crying on camera — but is not to give up, because this is so important," Handler said. "And it's easy to say throw in the towel and that we're going to leave. Or I am going to move to Spain, because I want to move to Spain! I really, really want to move to Spain right now. And everyone in my office is like, 'You have a responsibility. You have a voice, and you need to use it, and you need to be here.'"
Watch the video above.
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