Scream's All-Star Cast

Erik Knudsen, Rory Culkin, Marielle Jaffe and Hayden Panettiere

"For an audience that is so well-versed in Scream and in what happens and who becomes the killer, it's trickier to throw them a curveball," Panettiere, who plays Kirby in Scream 4, says. "I think they've done a really cool job with the script."

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