Salma Hayek is no fan of snakes.

The actress, 43, jumped out of her seat and climbed on her Grown Ups co-stars when she spotted the serpent on set while doing an interview with Extra to promote her newest flick (in theaters June 25).

"Somebody do something!" she shrieks. "Nooo!"

Assures Maria Bello, 43, “It’s OK. It’s going away.”

A frightened Hayek was then carried away by a member of the production team before she left the set altogether. "Thank you so much," she said, her voice trembling. (Ironically, Hayek seductively danced with a python -- while dressed in a skimpy bikini -- in 1996's From Dusk Till Dawn.)

"It was like a python. It was thick," Bello said after the surprise encounter. "Its head was like this like a cobra!"