Already have an account?
Get back to the

13 Best Acne Spot Treatments to Dramatically Improve Pimples Overnight

best-acne-spot-treatments
Shutterstock

Us Weekly has affiliate partnerships. We receive compensation when you click on a link and make a purchase. Learn more!

Looking for the best acne spot treatments to dramatically improve the appearance of pimples in a matter of hours? Spot treatment creams and pimple patches could reduce the size of blemishes, calm the redness of breakouts and shrink your acne while you sleep!

While it’s helpful to use any skincare product made for acne-prone skin, when you want fast results, a spot treatment is essential. Cream or serum-based treatments may work well for under-the-skin pimples or for daytime wear, while pimple patches “work best on open, draining, healing pustules, papules and cysts,” according to Dr. Amy Kassouf for Cleveland Clinic. There are microdart patches for deep blemishes as well! Ready to see the best acne spot treatments for your specific concerns? Shop below!

The 13 Best Acne Spot Treatments

COSRX Acne Pimple Patch Absorbing Hydrocolloid Original 3 Size Patches for Blemishes and Zits Cover, Spot Stickers for Face and Body, Not Tested on Animals, No Toxic Ingredients (120 Count (Pack of 5))
COSRX
You save: 22%

Best Overall Acne Spot Treatment: COSRX Acne Pimple Patch

$14$18
  • Pros:
  • Cons:
  • 120 patches per order
  • Very affordable
  • Also can be used for body acne
  • May not work as well on deep blemishes
  • You may run out of certain patch sizes before others
  • No acne-fighting ingredients apart from the hydrocolloid
La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment Blemish Cream with Benzoyl Peroxide for Blackheads, Lightweight Sheerness, Safe For Sensitive Skin
La Roche-Posay

Best for Sensitive Skin: La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment

$23
  • Pros:
  • Cons:
  • Benzoyl peroxide and lipo-hydroxy acid penetrate pores for deep skin renewal
  • Dermatologist-tested, allergy-tested
  • Available in two sizes
  • Not for cystic acne
  • May be too drying on some skin types — don't use all over face!
  • May want to start with using every other day
Vichy Normaderm S.O.S Acne Rescue Spot Corrector, Acne Spot Treatment for Face with 10% Sulfur, Niacinamide & Glycolic Acid, Blemish Remover and Pimple Cream to Reduce Breakouts for Sensitive Skin
Vichy

Best for Hormonal Acne: Vichy Normaderm S.O.S. Acne Rescue Spot Corrector

$23
  • Pros:
  • Cons:
  • Fragrance-free
  • 96% of testers agreed the size of their existing blemishes was reduced
  • Skinny nozzle makes it easy to target small areas
  • Some shoppers don't like the natural sulfur scent
  • Only for nighttime use
  • Could potentially stain clothing
Peach Slices | Deep Blemish Microdarts | Acne Patch | Early Stage & Deep Pimples | Fast-Acting | Salicylic Acid | Tea Tree Oil | Niacinamide | Cica | Hyaluronic Acid | Spot Treatment | 9 Patches
Peach Slices

Best for Cystic Acne: Peach Slices Deep Blemish Microdarts

$6
  • Pros:
  • Cons:
  • Microdarts target early-stage and below-the-surface blemishes
  • Acne-fighting, anti-inflammatory ingredients: vitamin b3, salicylic acid, tea tree oil
  • Cruelty-free and clean
  • Only nine patches per pack
  • Should not use on whiteheads
  • Appearance of microdarts could initially scare shoppers
TULA Probiotic Skin Care Go Away Acne Spot Treatment | Acne Treatment, Clear Up Acne, Targets Breakouts & Prevents Future Acne, Contains Salicylic Acid and Probiotics | 0.5 fl. oz
TULA

Best for Mature Skin: TULA Go Away Acne Spot Treatment

$22
  • Pros:
  • Cons:
  • White-to-clear formula can be applied daytime or nighttime
  • Licorice helps brighten skin and fade acne marks
  • Tea tree oil and probiotic extract soothe and balance skin
  • May not be compatible with sensitive skin
  • Small tube
  • Potentially too drying for dry skin types
ZealSea Azelaic Acid 10% Facial Cream, for Redness Relief Face, Rosacea Acne Treatment, Pimple Pigmentation Blackhead, Balance Excess Sebum, Clarify Skin, Soothe Irritation,1 oz
ZealSea

Best for Rosacea: ZealSea Supra Azelaic Acid Cream

$21
  • Pros:
  • Cons:
  • Specifically formulated for redness relief/rosacea acne inhibition
  • Visible reduction in acne in as little as three days
  • Controls bacteria to prevent future acne as well
  • Intense — may need to wash off for first handful of uses
  • One shopper noted it arrived with too much packaging
  • Some may be put off by tingling effect
best-overnight-acne-treatments-amazon-bolden
BOLDEN

Best for Black Skin: Bolden Overnight Acne Spot Treatment

$14
  • Pros:
  • Cons:
  • Free of parabens and sulfates
  • Under $20
  • Cleome gynandra leaf extract manages excess sebum
  • Sulfur smell may be off-putting at first
  • Dropper design may cause product to drip past your acne spot
  • Not too many reviews yet
Mario Badescu Drying Lotion for All Skin Types| Blemish Spot Treatment with Salicylic Acid and Sulfur | Dries Surface Blemishes | 1 Fl Oz
Mario Badescu
You save: 18%

Best for Oily Skin: Mario Badescu Drying Lotion

$14$17
  • Pros:
  • Cons:
  • Excellent for whiteheads/surface blemishes
  • Could also help expedite the healing process for pimples just below the surface
  • A fan-favorite since the 1960s
  • Must supply your own cotton swabs to use
  • If you accidentally shake the bottle, you need to wait for it to settle again
  • Does not treat blackheads
best-acne-spot-treatments-amazon-burts-bees
Burt's Bees
You save: 58%

Best for Pregnancy: Burt's Bees Targeted Spot Treatment

$5$12
  • Pros:
  • Cons:
  • Dermatologist-tested
  • Made with naturally-derived tea tree, calendula, yarrow and parsley
  • Thousands of reviews
  • Not specifically pregnancy skincare
  • Shoppers say it could burn sensitive areas of face
  • Some may be put off by a drugstore brand
Peace Out Skincare Acne Dots. Hydrocolloid Anti-Acne Pimple Patches with Salicylic Acid and Vitamin A to Quickly Clear Blemishes (20 dots)
PEACE OUT

Best Patches: Peace Out Acne Healing Dots

$19
  • Pros:
  • Cons:
  • Available in multiple quantities
  • Could see visible results in just six hours
  • Satisfying to peel off
  • Avoid if you cannot use retinol
  • Could be noticeable if worn during the day
  • Some shoppers found them to be a little expensive
Hero Rescue Balm Post-Blemish Recovery Cream - Nourishing & Calming for Dry, Red Skin - Vegan, Dermatologist Tested (15ml, 0.5 fl. oz)
Mighty Patch

Best for Just-Popped Pimples: Hero Rescue Balm

$13
  • Pros:
  • Cons:
  • Available in two sizes
  • Clinically-tested, allergy tested
  • Also great for wearing after a pimple patch
  • One shopper said it's hard to blend into skin
  • Not for dry skin types
  • No concealing properties
Rael Acne Spot Treatment, Miracle Clear Soothing Spot Gel Pen - Acne Gel, Pimple and Blemish Treatment, for Early Stage Pimples, Pore Control, Easy Applicator, with Succinic Acid, Tea Tree and Cica, Vegan, Cruelty Free (4 ml, 0.14 oz)
Rael

Best Acne Pen: Rael Acne Spot Treatment

$14
  • Pros:
  • Cons:
  • Clean, fragrance-free, paraben-free
  • Helps target acne before it makes its true appearance
  • For all skin types
  • First use may require up to 50 clicks to release formula
  • Not for whiteheads
  • Only 0.14 fl oz
Solawave Bye Acne Spot Treatment, Red Light Therapy and Blue Light Therapy for Acne Treatment to Use Before Pimple Patches, Acne Light Therapy Device, Facial Skin Care Products, Face Care Must Haves
SolaWave

Best Device: Solawave Bye Acne Spot Treatment

$99
  • Pros:
  • Cons:
  • Two available colors
  • Only three minutes per session
  • May also address hyperpigmentation
  • Not for severe acne
  • The most expensive pick on the list
  • Takes longer to use than creams

Not done shopping? Explore more of our favorite finds below:

Lotions-For-Eczema-Stock-Photo

Related: The 10 Best Lotions for Eczema That Actually Provide Relief

tinted-tanning-spf-products

Related: 10 Tinted and Tanning Body SPF Finds for Flawless Skin

Before-After-Acne-Clear-Skin

Related: You Have to See the Before-and-After Snaps of This Cystic Acne Treatment

Got a Tip form close button
Got a tip for US?
We're All Ears for Celebrity Buzz!