Reese Witherspoon and Chelsea Handler
"She's a really great friend. She's the kind of person who will cancel all her plans if you're in a bad mood and you just want to sit on the couch and watch a movie," Witherspoon says of E! talk show host Handler, who is also pals with Jennifer Aniston and Charlize Theron. "She's really generous. She likes to give a lot of good gifts!"